Local Anesthetic Pain Killer Procaine ( Novocaine ) Raw Powder For
Pain Relif Cas 59-46-1
What is procaine?
Procaine is a local anesthetic. Procaine causes loss of feeling
(numbness) of skin and mucous membranes.
Procaine is used as an injection during surgery and other medical
and dental procedures.
Procaine may also be used for purposes other than those listed
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions, procaine is referred to generically as novocaine. It acts mainly as a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion-enhancing, and mood-enhancing effects.
acid diethylaminoethyl ester|
|PROCAINE Chemical Properties|
|Boiling point||378.78°C (rough estimate)|
|density||1.0604 (rough estimate)|
|refractive index||1.5430 (estimate)|
|PROCAINE Usage And Synthesis|
|Uses||inhibitor of sodium channel|
|Definition||ChEBI: A benzoate ester, formally the result of esterification of
4-aminobenzoic acid with 2-diethylaminoethanol but formed
experimentally by reaction of ethyl 4-aminobenzoate with
|Contact allergens||Procaine is a local anesthetic with para-amino function.
Sensitization mainly concerns the medical, dental, and veterinary
Used as a local anesthetic primarily in oral surgery
Procaine is an anesthetic agent indicated for production of local
or regional anesthesia, particularly for oral surgery. Procaine
(like cocaine) has the advantage of constricting blood vessels
which reduces bleeding, unlike other local anesthetics like
lidocaine. Procaine is an ester anesthetic. It is metabolized in
the plasma by the enzyme pseudocholinesterase through hydrolysis
into para-aminobenzoic acid (PABA), which is then excreted by the
kidneys into the urine.
Mechanism of action
Procaine acts mainly by inhibiting sodium influx through voltage
gated sodium channels in the neuronal cell membrane of peripheral
nerves. When the influx of sodium is interrupted, an action
potential cannot arise and signal conduction is thus inhibited. The
receptor site is thought to be located at the cytoplasmic (inner)
portion of the sodium channel. Procaine has also been shown to bind
or antagonize the function of N-methyl-D-aspartate (NMDA) receptors
as well as nicotinic acetylcholine receptors and the serotonin
receptor-ion channel complex.
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|Lidocaine||Tetracaine hydrochloride||Bupivacaine hydrochloride|
|Linocaine hydrochloride||Pramoxine hydrochloride||Dibucaine hydrochloride|
|Procaine||Articaine hydrochloride||Ropivacaine hydrochloride|
|Procaine hydrochloride||Benzocaine hydrochloride||Levobupivacaine Hcl|